Jianhua Yang

Current Address:                                                                          

2119 Derring Hall (0406)                                                                 

Department of Biological Sciences                                                 

Virginia Polytechnic Institute and State University            

Blacksburg, VA 24061

Tel: 540-231-5165 (lab)

Email: jianhuayang@gmail.com

Education:

Ph.D.   Biochemistry                                                                                                      2005

State University of New York at Buffalo, Buffalo, NY

Dissertation: The iron response regulator: a bridge between heme biosynthesis and iron metabolism in Bradyrhizobium japonicum    

M.S.     Virology                                                                                                             1997

Fudan University, Shanghai, China

Dissertation: Effects of the ribozyme to tobacco mosaic virus RNA in vivo

B.S.      Microbiology                                                                                                     1995

Fudan University, Shanghai, China

Dissertation: Expression and detection of ZEBRA protein from Epstein-Barr virus in E. coli

Research Experience:

Postdoctoral Associate   Department of Biological Sciences, Virginia Polytechnic and State University                                  2006-present

Regulation of the cell cycle and circadian clock in Xenopus laevis

 Ph.D.   Department of Biochemistry, State University of New York at Buffalo                                                                          1999-2005

Regulation of heme biosynthesis and iron metabolism in Bradyrhizobium japonicum

 Research Associate   Institute of Biochemistry and Cell Biology, the Chinese Academy of Sciences, Shanghai, China             1997-1999

Inhibition of shotgun-type ribozyme on the expression of a(1,3) gal epitope in mammalian cells

M.S.   Division of Virology, Department of Microbiology, Fudan University, Shanghai, China                                                   1994-1997

Effects of the ribozyme to tobacco mosaic virus RNA in vivo

B.S.   Department of Microbiology, Fudan University, Shanghai, China                                                                                       1990-1995

Expression and detection of ZEBRA protein from Epstein-Barr virus in E. coli

Publications:

[1]  Yang, J., Sangwan, I., Lindemann, A., Hauser, F., Hennecke, H., Fischer, H. M., and O’Brian, M. R. (2006). Bradyrhizobium japonicum senses iron through the status of heme to regulate iron metabolism. Mol Microbiol 60 (2), 427-437. (Full Text) (PDF)

[2]  Yang, J.¹, Panek, H. R.¹, and O'Brian, M. R. (2006). Oxidative stress promotes degradation of the Irr protein to regulate haem biosynthesis in Bradyrhizobium japonicum. ¹Equal contribution. Mol Microbiol 60 (1), 209-218. (PDF)

[3]  Yang, J., Ishimori, K., and O'Brian, M. R. (2005). Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein. J Biol Chem 280, 7671-7676. (Full Text) (PDF)

[4]  Yang, J.,  Sangwan, I. and O’Brian, M. R. The Bradyrhizobium japonicum Fur protein is an iron-responsive regulator in vivo. (submitted to Mol Genetics & Genomics)

[5]  Yang, J., Friedman, Y., and O'Brian, M. R. Regulation of heme and iron metabolism in Bradyrhizobium japonicum. Curr Plant Sci Biot 41: 303-306, 2005. Editors: Wang Y., Lin M., Tian Z., Elmerich C., and Newton W.E. Springer, Netherlands.

[6]  Yang Jian-Hua, Wang Hua-Lin, Yu Shan-Qian. Construction of a ribozyme transgenic plasmid vector and its inhibition to TMV infection in tobacco protoplasts (1998). Journal of Fudan University (Natural Science) (In Chinese), 37(4): 547-550.

[7]  Jin Chun-Yang, Yang Jian-Hua, Yue Yin, Yu Shan-Qian, and Zhang Dao-Dao. Chemical synthesis of ribozyme and its cleavage activity to TMV-RNA in vitro (1998). Journal of Fudan University (Natural Science) (In Chinese), 37(2): 191-196.

Fellowship:

[1]  AdvanceVT Post-doctoral Fellowship 2006-2007. National Science Foundation the ADVANCE program, Virginia Polytechnic Institute and State University.

Honors and Awards:

[1]  The Biochemistry Dissertation Research Recognition Award 2006. State University of New York at Buffalo.

[2]  Honorable Mention for Oral Presentation (2004). In: Biochemistry Research Day, Department of Biochemistry, State University of New York at Buffalo.   May, 2004.

[3]  Best Oral Presentation (2003). In: Biochemistry Research Day, Department of Biochemistry, State University of New York at Buffalo. May, 2003.

[4]  Outstanding Graduate Student Fellowship (1996). Fudan University, Shanghai, China.

[5]  Renmin Fellowship (1991-1994). Fudan University, Shanghai, China.