Robert W Grange, Ph.D. Associate Professor 321 Wallace Hall Blacksburg, VA 24061 Phone: (540) 231-2725 Fax: (540) 231-3916 Email: rgrange@vt.edu Education Doctor of Philosophy in Kinesiology - University of Waterloo, Waterloo, Ontario, Canada. 1993. Master of Science in Kinesiology - University of Washington, Seattle, WA., U.S.A. 1984. Bachelor of Physical Education - University of British Columbia, Vancouver, British Columbia, Canada. 1979. Positions 1993-1998 Postdoctoral Research Fellow. Department of Physiology. University of Texas Southwestern Medical Center, Dallas Texas. 1998-1999 Assistant Instructor and Director for Muscle Physiology Core, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas. 1999-2005 Assistant Professor, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic and State University, Blacksburg, Virginia. 2005- Associate Professor, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic and State University, Blacksburg, Virginia. Publications (1998-Present) Gainer, TG, Wang W, and Grange RW. 2007. “Duchenne Muscular Dystrophy”. Chapter in, Skeletal Muscle Damage and Repair: Mechanisms and Interventions. Ed. By Peter M. Tiidus. Human Kinetics, Inc. Accepted. Grange, RW and JA Call. 2006. Recommendations to define exercise prescription for Duchenne muscular dystrophy. Ex, and Sports Sci, Rev. Jan., 2007. Wolff, AV, Niday A K, Voelker KA, Call JA, Evans NP, Granata KP, Grange, RW. 2006. Passive mechanical properties of maturing EDL are not affected by lack of dystrophin. Muscle and Nerve 34:304-312. Lowe, DA, Williams, BO, Thomas DD and Grange RW. 2006. Molecular and cellular contractile dysfunction of dystrophic muscle from young mice. Muscle and Nerve 34:92-100. Anderson B, Christiansen SP, Grandt S, Grange RW and McLoon LK. 2006. Increased Extraocular Muscle Strength with Direct Injection of Insulin-like Growth Factor I. Inv Ophthal & Vis Sci. 47(6):2461-2467. Pline AM, Madigan ML, Nussbaum, MA and Grange RW. 2005. Lumbar extensor fatigue and Circumferential Ankle Pressure Impair Ankle Joint Motion Sense. Neuroscience Letters. 390(1):9-14. Liu M, Yue Y, Harper SQ, Grange RW, Chamberlain JS, and Duan D. 2004. Adeno-associated Virus-mediated Micro-dystrophin Expression Protects Young Mdx Muscle. Mol. Ther. 11(2):245-255. Liu D, Jiang H and Grange RW. 2005. Genistein activates the cAMP signaling pathway in vascular endothelial cells and protects endothelial barrier function. Endocrin. 146: 1312–1320. Draper KE, Wang Q, Williams BO, and Grange RW. 2004. “Duchenne Muscular Dystrophy”, in Encyclopedic Reference of Neuroscience. Springer. Chin ER, Grange RW, Viau F, Humphries C, Shelton J, Bassel-Duby R, Michel RN, and Sanders Williams R. 2003. Phenotypic alterations in slow-twitch muscle from transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. J. of Physiology (London), 547:649-663. Grange, R.W., T. Gainer, K. M. Marschner, R. J. Talmadge and J.T. Stull. 2002. Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress. Am. J. Physiol. (Cell 283): 1090-1101. Grange, R.W., A. Meeson, E.R. Chin, K.S. Lau, J.T. Stull, J.M. Shelton, R. Sanders Williams, and D. J. Garry. 2001. Functional and molecular adaptations in skeletal muscle of myoglobin mutant mice. Am.J. Physiol. (Cell 281): C1487-C1494. Grange, R.W., E. Isotani, K.S. Lau, K.E. Kamm, and P. L. Huang, and J.T. Stull. 2001. Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch skeletal muscles. Physiol. Genomics. 5: 35-44. Grady, R.M., R.W. Grange, K. S. Lau, M.M. Maimone, M.C. Nichol, J.T. Stull, and J.R. Sanes. 1999. Role for α-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies. Nature (Cell Biology). 1(4): 215-220. Garry, D.J., G.A. Ordway, J.N. Lorenz, N.B. Radford, E.R. Chin, R.W. Grange, R. Bassel-Duby, and R. S. Williams. 1998. Mice without myoglobin. Nature 395:905-908. Abstracts Evans NP, Call J.A., Niday AK, Voelker KA, Wolff AV, Grange RW. Increased cytokines, chemokines, and extracellular matrix proteins in 21-day mdx and mdx:utrophin-/- serum and diaphragm muscles. New Directions in Skeletal Muscle Biology and Disease, Dallas, Apr 23-26, 2006. Niday, AK, Wolff A, Voelker KA, Call JA, Evans NP, Granata KP, Grange RW. Morphology, and EDL stress production and passive mechanical properties of maturing mdx and mdx:utrophin-/- mice. New Directions in the Biology and Disease of Skeletal Muscle, Dallas, Apr 23-26, 2006. Ward CW, Voelker, K, Grange RW, Shtifman A. Local calcium release events in wildtype and dystrophic adult myofibers. New Directions in the Biology and Disease of Skeletal Muscle, Dallas, Apr 23-26, 2006. Wolff, AV, Niday A K, Voelker KA, Call JA, Evans NP, Granata KP, Grange, RW. Active and passive mechanical properties of maturing dystrophic edl muscles. American Society of Biomechanics (ASB) at Virginia Tech, Blacksburg, VASeptember 6-9, 2006 Wolff, AV, Niday A K, Voelker KA, Call JA, Evans NP, Granata KP, Grange, RW. Passive mechanical properties of maturing EDL are not affected by lack of dystrophin. New Directions in the Biology and Disease of Skeletal Muscle, Dallas, Apr 23-26, 2006. Wolff, AV, Niday A K, Voelker KA, Call JA, Evans NP, Granata KP, Grange, RW. Passive mechanical properties of maturing EDL are not affected by lack of dystrophin. Virginia Tech Graduate Research Symposium Mar 29, 2006 Lund TC, Nelson SA, Grange RW and Lowe DA. Telomere shortening in skeletal muscle from mdx mice. Am Soc Cell Biol, San Francisco, Dec 10-14, 2005. Wang Q, Draper KE and Grange RW. Calpain activity is transiently increased in maturing dystrophic skeletal muscle. The Integrative Biology of Exercise. Austin, Oct. 6-9, 2004. Lowe DA, Williams BO Thomas DD and Grange RW. Structural and functional alterations of myosin in dystrophic muscle. The Integrative Biology of Exercise. Austin, Oct. 6-9, 2004. Lowe DA, Grange RW and Thomas DD. Structural and functional alterations of myosin in dystrophic muscle. (post weaning muscle) Univ. Minnesota Skeletal Muscle Symposium, May 26, 2004. Draper KE and Grange RW. Structure-bound calpain activity is increased in maturing dystrophic muscle. New Directions in the Biology and Disease of Skeletal Muscle, San Diego, Jan. 25-28, 2004. Nakamura A, Bassaganya-Riera J, Grange RW and Houston ME. CD4+ T cell-depleted Splenocytes in maturing MDX Mice. Experimental Biology, Washington, DC, April 18-21, 2004. Lowe DA, Grange RW and Thomas DD. Structural and functional alterations in dystrophic muscle. (Aged muscle.) Univ. Minnesota Skeletal Muscle Symposium, May 25, 2003. Gainer TG, Elgert KD, Rittler MR, Draper KE, Sha W, and Grange RW. Genome profiling of inflammatory markers during early maturation of dystophic mdx:utrophin-/- mice. Experimental Biology Conference, San Diego, CA, April 11-15, 2003. Rittler MR, Lowe DA, Gainer TG, Lees SJ, Williams JH, and Grange RW. Compromised contractile apparatus in maturing dystrophic skeletal muscles. Experimental Biology Conference, San Diego, CA, April 11-15, 2003. Grange RW, Ordway GA, and Stull JT. Stress generation and proteasome activity in mdx:utrophin-/- and mdx muscles. The Physiologist 43(4): 366, 2000. Poster, The Integrative Biology of Exercise Conference, September 20-23, 2000, Portland, Maine. Grange RW. Stress generation in mdx:utrophin-/- and mdx EDL of young mice. Program Addendum p. 9. Poster, Experimental Biology Conference, an Diego, April 15-18, 2000. Grange RW, Lau KS, Kamm KE and Stull JT. Neuronal nitric oxide synthase contributes to vascular relaxation in contracting EDL muscles in vitro. FASEB J 13: (5) A1066-A1066 Part 2 Suppl. S 1999. Poster, Experimental Biology Conference, 1999, Washington, D.C. Lau KS, Grange RW, Kamm KE, and Stull JT. cGMP formation in contracting fast-twitch skeletal muscle is inhibited in muscles lacking neuronal nitric oxide synthase. FASEB J 13: (5) A1066-A1066 Part 2 Suppl. S 1999. Poster, Experimental Biology Conference, 1999, Washington, D.C. Chin ER, Grange RW, Maier M, Bassel-Duby RS and Williams RS. Altered contractile function in slow-twitch muscle from transgenic mice overexpressing parvalbumin. American College of Sports Medicine Meeting 1999, Seattle, Washington. Meeson AP, Radford N, Grange R, Chin E, Elterman J, Williams RS, Garry DJ. Adaptive mechanisms in myoglobin mutant mice. Circulation 100: (18) 4045, Suppl. S 1999. Research Support Ongoing Research Support as a PI NIAMS/NIH R01-AR049881-01A1 Grange (PI-30%) 10/1/04-6/30/07 Pathogenic mechanisms that initiate Duchenne Muscular Dystrophy. The long range goal of this research program is to identify the pathogenic mechanisms that lead to onset of Duchenne’s Muscular Dystrophy (DMD) using two dystrophic mouse models. Collaborators: D. Thomas and D. Lowe, Department of Biochemistry, University of Minnesota; C Ward, Department of Biomedical Science, University of Maryland School of Nursing; J Williams, Department of Human Nutrition, Foods and Exercise, Virginia Tech. Completed Research Support Muscular Dystrophy Association Grange (PI) 7/1/03-12/31/04 Mechanisms of force loss in Duchenne Muscular Dystrophy. Collaborators: D. Thomas and D. Lowe, Department of Biochemistry, University of Minnesota. Muscular Dystrophy Association Grange (PI) 7/1/98-6/30-01 Pathogenic mechanisms in Duchenne Muscular Dystrophy. Co-PI: J.T. Stull, Chairman and Bashour Distinguished Professor of Physiology, University of Texas Southwestern Medical Center at Dallas. Instructional Responsibilities Exercise Physiology (HNFE 3804) Exercise and Neuromuscular Adaptations (HNFE 4844) Kinesiology (HNFE 3824) Graduate Seminar (HNFE 5044) Undergraduate seminar (HNFE 4004; Writing Intensive)